Sonoclot Analyzer, ACT Machine India, Thromboelastography, Cardiac Surgery, Liver Transplant

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A-535 2002 Differential Effects of Hirudin and Heparin on the Whole Blood Clot Formation Jaime Torres, M.D.; Nobukazu Sato, M.D.; Kenichi A. Tanaka, M.D.; Fania Szlam, M.M.S.; Jerrold H. Levy, M.D. Anesthesiology, Emory University School of Medicine, Atlanta, Georgia Introduction: Although heparin (Hep) is widely used for anticoagulation during cardiac or vascular surgery, some patients may suffer from serious complications such as heparin-induced thrombocytopenia. Recombinant hirudin (rHir), a direct thrombin inhibitor, is used as a heparin alternative1, 2. However, the effects of rHir on the whole blood clot formation is not completely understood. Therefore, we designed a study to compare the effects of rHir and Hep using the Sonoclot, a viscoelastic coagulation monitor. Methods: After institutional approval and informed consent, 5 healthy volunteers were included in this protocol. Blood samples were collected int