Sonoclot Analyzer, ACT Machine India, Thromboelastography, Cardiac Surgery, Liver Transplant

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Appropriate Dosage Of Unfraction Heparin And Low Molecular Weight Heparin In Hemodialysis Patients [Article in Chinese] Xiao Q, Sun XF, Zhang D, Ma ZF, Wu MG, Wang H, Chen XM. Institute of Nephrology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China.   Abstract OBJECTIVE: To investigate the appropriate dose of unfraction heparin and low molecular weight heparin (LMWH) in hemodialysis patients.   METHODS: Thirty-eight hemodialysis patients were enrolled and randomly allocated into four groups.The initial bolus dose for the Low-dose (LH, n = 10) and high-dose heparin (HH, n = 10) groups were 35 U/kg and 55 U/kg, respectively.The repeated maintenance dose for both groups were 10 U/kg.h and 16 U/kg.h, respectively. Fragmin were administered as single bolus (60 U/kg or 80 U/kg) at 30 minutes before hemodialysis in Low-dose LMWH(LLMWH, n = 10) and High-dose LMWH (HLMW, n = 8) group, respectively. Furthermore, the dialysis circuits in LUFH and LLMWUF

Fondaparinux is a new anticoagulant that interacts with antithrombin III and activated coagulation factor X resulting in an inhibition of the coagulation system. It has been successful in doses of 2.5 mg for thromboprophylaxis as well as in higher therapeutic doses of 5- 7.5 mg. No optimal method for monitoring the effects of fondaparinux has been proposed. The aim of the present study was to investigate whether a viscoelastic coagulation analyzer, the Sonoclot (Sienco, Denv er, Colorado, USA), could be used for in- vitro monitoring of fondaparinux.  Different concentrations of fondaparinux were added in-vitro to whole blood taken from eight volunteers. The blood samples mixed with the various amounts of fondaparinux were analyzed using the Sonoclot. The whole- blood activated partial thromboplastin time with the Hemochron Jr (IT C, Edison, New Jersey , USA) was used as the reference coagulation analysis. All analyses were started expeditiously , within 30 s from sampling, and were per