Sonoclot Analyzer, ACT Machine India, Thromboelastography, Cardiac Surgery, Liver Transplant

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S ono c l o t A na l yz e r an d P l ate l e t A gg r ego m et r y D ete c t P l ate l e t R e c epto r ( G P II b/ III a ) B l o c k ad e Y u e D ong , M . D . ; G r ego r y A . N utta ll , M . D . ; W illi a m C . O li v e r , M . D . ; M a r k H . E r eth , M . D . A ne s the s i o l og y , M a y o C li n i c , R o c he s te r , M i nne s ota , U n i te d S tate s [ B a c k g r ound ] A b c i x i m a b b l o c k s th e m a j o r p l ate l e t s u r f a c e r e c epto r ( G P II b/ III a ), w h i c h i s c r i t i c a l t o p l ate l e t agg r egat i on . P r a c t i c a l m ean s t o m on i to r p l ate l e t f un c t i o n i n pat i ent s o n ab c i x i m a b unde r go i n g e m e r gen c y c a r d i a c s u r ge r y i s needed . [ M ethod s ] A f te r I n s t i tut i ona l R e v i e w B oa r d app r o v a l an d i n f o r m e d c on s ent , b l oo d s a m p l e s w e r e d r a w n f r o m ...

J Thorac Cardiovasc Surg.  2006 Jun;131(6):1314-22. Platelet function monitoring with the Sonoclot analyzer after in vitro tirofiban and heparin administration. Tucci MA ,  Ganter MT ,  Hamiel CR ,  Klaghofer R ,  Zollinger A ,  Hofer CK . Source Institute of Anaesthesiology, University Hospital Lausanne, Lausanne, Switzerland. Abstract OBJECTIVE: Reliable platelet function monitoring is desirable in patients treated with glycoprotein IIb/IIIa receptor inhibitors. The aim of the present laboratory-based study was to assess platelet function after administration of clinically relevant doses of the glycoprotein IIb/IIIa antagonist tirofiban with or without heparin by using Sonoclot (Sienco Inc) and platelet aggregometry. METHODS: Tirofiban (0-100 ng x mL(-1)) and heparin (0 or 1 U x mL(-1)) were added to blood samples obtained from 20 healthy volunteers. Coagulation analysis was performed on citrated whole blood by using the So...

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Sonoclot Analyzer and Platelet Aggregometry Detect Platelet Receptor (GPIIb/IIIa) Blockade Yue Dong, M.D.; Gregory A. Nuttall, M.D.; William C. Oliver, M.D.; Mark H. Ereth, M.D. Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States [Background] Abciximab blocks the major platelet surface receptor (GPIIb/IIIa), which is critical to platelet aggregation. Practical means to monitor platelet function in patients on abciximab undergoing emergency cardiac surgery is needed. [Methods] After Institutional Review Board approval and informed consent, blood samples were drawn from 20 healthy volunteers. Celite activated Sonoclot analysis and ADP activated Platelet Poor Plasma (PRP) aggregometry were completed after addition of abciximab. The Sonoclot analysis and ADP activated PRP aggregometry were used to detect platelet function. The data was analyzed by student's t test and P<0.05 is statistically significan...