Sonoclot Analyzer, ACT Machine India, Thromboelastography, Cardiac Surgery, Liver Transplant

Sonoclot (SC1) ACT Machine incorporates Sonoclot's Proprietary Visco-Elastic technology and is extremely sensitive to the developing clot. Normal ACT Machines mechanically detect mature clot to report Activated Clotting Time which takes into account cumulative activity of Factors, Fibrin gel & Platelets to form a mature clot. On the other hand Sonoclot ACT Machine starts monitoring the viscosity changes, which is the first component to change when the coagulation cascade is triggered by the respective activators. Factor Xa triggers Prothrombin to Thrombin (Factor IIa) the sample is still in the liquid phase. As Thrombin forms it triggers Fibrinogen to Fibrin Polymerization the sample starts to gel and the viscosity starts increasing. Sonoclot ACT Machine is very sensitive to this changing viscosity and first reports ACT, which is a function of Factor Xa activity. Once the ACT re...

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A-535 2002 Differential Effects of Hirudin and Heparin on the Whole Blood Clot Formation Jaime Torres, M.D.; Nobukazu Sato, M.D.; Kenichi A. Tanaka, M.D.; Fania Szlam, M.M.S.; Jerrold H. Levy, M.D. Anesthesiology, Emory University School of Medicine, Atlanta, Georgia Introduction: Although heparin (Hep) is widely used for anticoagulation during cardiac or vascular surgery, some patients may suffer from serious complications such as heparin-induced thrombocytopenia. Recombinant hirudin (rHir), a direct thrombin inhibitor, is used as a heparin alternative1, 2. However, the effects of rHir on the whole blood clot formation is not completely understood. Therefore, we designed a study to compare the effects of rHir and Hep using the Sonoclot, a viscoelastic coagulation monitor. Methods: After institutional approval and informed consent, 5 healthy volunteers were included in this protocol. Blood samples were collected int...

J Cardiothorac Vasc Anesth. 2008 Oct;22(5):670-4. Epub 2008 Mar 24. Sonoclot analysis in coronary artery surgery: a comparison between patients with unstable coronary artery disease treated with enoxaparin before surgery and patients with stable coronary artery disease not treated with enoxaparin. Pleym H, Wahba A, Bjella L, Stenseth R. Department of Cardiothoracic Anesthesia and Intensive Care, St Olav University Hospital, Trondheim, Norway. hilde.pleym@stolav.no Abstract OBJECTIVES: To investigate whether perioperative Sonoclot analyses could identify differences in hemostatic function between a group of patients with unstable coronary artery disease treated with low-molecular-weight heparin until the evening before surgery and a group of patients with stable coronary artery disease not treated with lowmolecular-weight heparin. DESIGN: Prospective and observational investigation. SETTING: A university hospital, single institution. PARTICIPANTS: Patien...