Sonoclot Analyzer, ACT Machine India, Thromboelastography, Cardiac Surgery, Liver Transplant

Intraoperative Monitoring of Platelet Activity for Patients with Reactive Thrombocytemia and the Mechanism of Adenosine-5’-Diphosphate-Induced Blood Coagulation Shinji Kohro, M.D., Ph.D., Michiaki Yamakage, M.D., Ph.D., Kaori Satoh, M.D., Akiyoshi Namiki, M.D., Ph.D. Anesthesiology, Sapporo Medical Univ. Sch. of Med., Sapporo, Hokkaido, Japan.   INTRODUCTION: Patients with thrombocytemia are at the risk for development of thromboembolism, especially in the perioperative period. We intraoperatively monitored adenosine-5’-diphosphate (ADP)-induced whole blood coagulation in patients with thrombocytemia using a platelet aggregation monitor (WBA analyzer™; SSR Engineering Co., Kanagawa, Japan). To determine the mechanism of ADP-induced platelet activation, we also investigated ADP-induced blood coagulation using a standard blood viscometer ( Sonoclot ™; Scienco Co., Wheat Ri...

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A-535 2002 Differential Effects of Hirudin and Heparin on the Whole Blood Clot Formation Jaime Torres, M.D.; Nobukazu Sato, M.D.; Kenichi A. Tanaka, M.D.; Fania Szlam, M.M.S.; Jerrold H. Levy, M.D. Anesthesiology, Emory University School of Medicine, Atlanta, Georgia Introduction: Although heparin (Hep) is widely used for anticoagulation during cardiac or vascular surgery, some patients may suffer from serious complications such as heparin-induced thrombocytopenia. Recombinant hirudin (rHir), a direct thrombin inhibitor, is used as a heparin alternative1, 2. However, the effects of rHir on the whole blood clot formation is not completely understood. Therefore, we designed a study to compare the effects of rHir and Hep using the Sonoclot, a viscoelastic coagulation monitor. Methods: After institutional approval and informed consent, 5 healthy volunteers were included in this protocol. Blood samples were collected int...

Disseminated Intravascular Coagulation (DIC) The DIC process can be divided into three stages: • Hypercoagulable (Stage I) • Secondary fibrinolytic (Stage II) • Hypocoagulable (Stage III) Hypercoagulable (Stage I) DIC is commonly initiated through release of tissue factor (TF) and FVIIa activation of the extrinsic pathway, resulting in a deposition of thrombin in the microcirculation system. TF is normally contained within the cellular membrane and encrypted. However, traumatic tissue injury, required major resuscitation, or major surgery, exposes TF to the bloodstream. TF expression can also occur when monocytes are activated by sepsis, endotoxin, the presence of cancerous cells, or in pregnancy when amniotic fluid penetrates the maternal blood stream. In summary, the release of TF, together with FVIIa, initiates the extrinsic coagulation cascade and, if it is not anticoagulated accordingly, with heparin low molecular weight heparin (LMWH), or activated protein C ...

Sonoclot - ACT Machine India Sonoclot SC1 Analyzer calculates onset of ACT and Clot Rate for in vitro coagulation studies by monitoring mechanical changes that occur to blood samples during hemostasis. Features: o ACT & Clot Rate Results o Separate Results for Factor Xa & Thrombin (IIa) Inhibition o Information on Coagulation Factors & Fibrinogen in one Simple Test o Accurate Heparin Anti-Coagulation Management o Residual Heparin Detection o Low Molecular Weight Heparin Management o Improved Hemostasis Management o Reduced Usage of Blood Products o Portable for use in OR, Cath Lab, ICU or Lab. o Simple QC Procedure o Microprocessor Controlled o On Board Data Storage and Computer Connectivity More Details on: http://www.lifediagnostica.com/

Sonoclot SC1 Analyzer calculates onset of ACT and Clot Rate for in vitro coagulation studies by monitoring mechanical changes that occur to blood samples during hemostasis. The mechanism is a tubular probe that moves up and down within a blood sample. This produces a series of electronic signals that are processed by a microcomputer. Sonoclot SC1 incorporates Sienco's patented whole blood viscoelastic clot detection mechanism. It provides effective clinical hemostasis management for operating rooms, coagulation labs, STAT labs, and intensive care units. For More Details please follow: http://www.lifediagnostica.com/