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Showing posts from May, 2012

Platelet function monitoring with the Sonoclot analyzer after in vitro tirofiban and heparin administration

J Thorac Cardiovasc Surg.  2006 Jun;131(6):1314-22. Platelet function monitoring with the Sonoclot analyzer after in vitro tirofiban and heparin administration. Tucci MA ,  Ganter MT ,  Hamiel CR ,  Klaghofer R ,  Zollinger A ,  Hofer CK . Source Institute of Anaesthesiology, University Hospital Lausanne, Lausanne, Switzerland. Abstract OBJECTIVE: Reliable platelet function monitoring is desirable in patients treated with glycoprotein IIb/IIIa receptor inhibitors. The aim of the present laboratory-based study was to assess platelet function after administration of clinically relevant doses of the glycoprotein IIb/IIIa antagonist tirofiban with or without heparin by using Sonoclot (Sienco Inc) and platelet aggregometry. METHODS: Tirofiban (0-100 ng x mL(-1)) and heparin (0 or 1 U x mL(-1)) were added to blood samples obtained from 20 healthy volunteers. Coagulation analysis was performed on citrated whole blood by using the Sonoclot analyzer. The glass be

Assessment of heparin anticoagulation by Sonoclot Analyzer in arterial reconstruction surgery

Authors Bok Lee 1 , Noori Al-Waili 2, 3 , Glenn Butler 2 , Khelod Salom 2 1 Department of Surgery, New York Medical College, New York, NY, USA 2 Life Support Technology Group, New York, NY, USA 3 King Saud University, Riyadh, Kingdom of Saudi Arabia Abstract Since heparin has been in use as an anticoagulant during vascular surgery and medical problems such as DVT or pulmonary embolism, there has been no consensus as to the best method of monitoring its effect on anticoagulation. In this study we used Sonoclot Analyzer to detect hemostasis changes resulting from heparin administration. The study involved 16 randomly selected male patients undergoing peripheral reconstructive surgery. Blood samples were drawn and analyzed in the operating room on the Sonoclot Coagulation and Platelet Function Analyzer. Results showed that patients respond to heparin differently. The Sonoclot monitors the hemodynamics of blood using four variables: SonACT (activated clot

Hyperhomocysteinemia and hypercoagulability in primary biliary cirrhosis

Abstract AIM : T o asses s th e h ypercoagulabili t y i n PB C an d   its relationship with homocysteine (HCY ) an d v ariou s component s o f th e haemostati c system. METHODS: W e i n v estigated 51 PBC patients (43F/8M; mea n age : 6 3 ± 13. 9 y r ) an d 10 2 healt hy   subject s (86 women/16 men; 63 ± 13 yr), and e v aluated the haemo- stati c proces s i n whol e bloo d   b y th e Sonoclo t analysis an d th e platele t f unctio n   b y P F A -10 0 device . W e then measure d HC Y   ( f astin g   an d afte r methionin e loading), tissu e   f acto r ( TF) , thrombin - antithrombi n comple x es ( TA T ), D-dimer (D-D), thrombomodulin ( TM), f olic acid, vitamin B6 and B12 plasma le v els. C677T 5,10-met h yl- enetet r a h ydro f olat e reductas e   (MTHFR )   polymorphism w as analyzed. RESU L TS: Sonoclot R A TE v alues of patients were sign i ficantly ( P < 0.001) higher

Blood coagulation monitoring during liver transplantation / transplant: Sonoclot Thrombography analysis and laboratory tests

BACKGROUND: Aim of this paper is to validate blood coagulation data obtained using the Sonoclot thromboelastography analyser (Sienco Inc., Morris on, USA) by means of standard laboratory tests during orthotopic liver transplantation / transplant(OLT). METHODS: DESIGN: comparative study between laboratory data and Sonoclot analysis on simultaneously collected blood samples . SETTING: National Health System Liver Trans plantation Center. PATIENTS: Fifty-one patients , both males and females , affected by terminal hepatic disease submitted to OLT were enrolled in the study. DATA COLLECTION: simultaneous blood samples were collected during the pre-anhepatic, anhepatic and pos t-reperfusion phases of OLT; coagulation status was assessed by means of either standard Laboratory tests (INR, aPTT, Fibrinogen, PLT, D-Dimer) and Sonoclot analyser data (SonACT, Rate, Tim e to Peak, Downward Deflection); a statistical analysis was performed (Pearsons chi(2) test).